Antibiotik Profilaksis pada Tindakan Bedah

Johan Indra Lukito

Abstract

Antibiotik profilaksis pra-operasi didefinisikan sebagai pemberian antibiotik sebelum operasi untuk mengurangi risiko infeksi pasca operasi. Antibiotik profilaksis optimal untuk pembedahan idealnya sesuai pedoman penggunaan antibiotik profilaksis atau pedoman lokal. Kriteria antibiotik profilaksis dalam pembedahan yang tepat meliputi tepat indikasi, tepat jenis antibiotik, tepat dosis, tepat rute, tepat waktu dan durasi pemberian.

Preoperative antibiotic prophylaxis is defined as administration of antibiotics prior to surgical procedure to decrease postoperative infection risk. The optimal antibiotic prophylaxis for surgery is ideally in accordance with the guidelines. The key elements of appropriate surgical antimicrobial prophylaxis prescribing include correct indication, antimicrobial, drug dose, route, timing of administration and duration.

Full Text:

PDF

References

Bratzler DW, Dellinger EP, Olsen KM, Perl TM, Auwaerter PG, Bolon MK et al. Clinical practice guidelines for antimicrobial prophylaxis in surgery. Am J Health Syst Pharm. 2013;70(3):195-283. doi: 10.2146/ajhp120568.

Crader MF, Varacallo M. Preoperative Antibiotic Prophylaxis. Medscape [Internet] 2019 [Cited 2019 August 8]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK442032/

Ierano C, Nankervis JM, James R, Rajkhowa A, Peel T, Thursky K. Surgical antimicrobial prophylaxis. Aust Prescr. 2017; 40(6): 225–9.

Peraturan Menteri Kesehatan Republik Indonesia Nomor 8 Tahun 2015 Tentang Program Pengendalian Resistensi Antibiotik Di Rumah Sakit. [Internet] 2015 [Cited 2019 August 8]. Available from: https://ghsaindonesia.files.wordpress.com/2016/02/peraturan-menteri-kesehatan-ri-no-8-tahun-2015-tentang-pengendalian-resistensi-antibiotik -di-rumah-sakit.pdf

Tarchini G, Liau KH, Solomkin JS. Antimicrobial Stewardship in Surgery: Challenges and Opportunities. Clin. Infect. Dis. 2017;64(suppl_2):S112-4

eTG complete [Internet] 2017[Cited 2019 August 8]. Available from: www.tg.org.au

Berríos-Torres SI, Umscheid CA, Bratzler DW, Leas B, Stone EC, Kelz RR, et al. Healthcare Infection Control Practices Advisory Committee Centers for Disease Control and Prevention guideline for the prevention of surgical site infection, 2017. JAMA Surg 2017;152:784-91.

National Institute for Health and Care Excellence. Surgical site infections: prevention and treatment. Clinical guideline 74. London: NICE; 2008. Updated 2017. [Internet] 2017[Cited 2019 August 8]. Available from: www.nice.org.uk/guidance/cg74

Heal CF, Buettner PG, Drobetz H. Risk factors for surgical site infection after dermatological surgery. Int J Dermatol 2012;51:796-803.

Smith SC, Heal CF, Buttner PG. Prevention of surgical site infection in lower limb skin lesion excisions with single dose oral antibiotic prophylaxis: a prospective randomised placebo-controlled double-blind trial. BMJ Open 2014;4:e005270.

Scottish Intercollegiate Guidelines Network. Antibiotic prophylaxis in surgery. SIGN 104. Edinburgh: SIGN; 2008. Updated 2014. [Internet] 2014[Cited 2019 August 8]. Available from: http://www.sign.ac.uk/sign-104-antibiotic-prophylaxis-in-surgery.html

Unger NR, Stein BJ. Effectiveness of pre-operative cefazolin in obese patients. Surg Infect (Larchmt) 2014;15:412-6.

Ho VP, Nicolau DP, Dakin GF, Pomp A, Rich BS, Towe CW, et al. Cefazolin dosing for surgical prophylaxis in morbidly obese patients. Surg Infect (Larchmt) 2012;13:33-7.

Allegranzi B, Bischoff P, de Jonge S, Kubilay NZ, Zayed B, Gomes SM, et al. WHO Guidelines Development Group New WHO recommendations on preoperative measures for surgical site infection prevention: an evidence-based global perspective. Lancet Infect Dis 2016;16:e276-87.

Duffield A, Sultan P, Riley ET, Carvalho B. Optimal administration of cefazolin prophylaxis for cesarean delivery. J Perinatol 2017;37:16-20.

Mackeen AD, Packard RE, Ota E, Berghella V, Baxter JK. Timing of intravenous prophylactic antibiotics for preventing postpartum infectious morbidity in women undergoing cesarean delivery. Cochrane Database Syst Rev 2014;(12):CD009516.

Lador A, Nasir H, Mansur N, Sharoni E, Biderman P, Leibovici L, et al. Antibiotic prophylaxis in cardiac surgery: systematic review and meta-analysis. J Antimicrob Chemother 2012;67:541-50.

Mertz D, Johnstone J, Loeb M. Does duration of perioperative antibiotic prophylaxis matter in cardiac surgery? A systematic review and meta-analysis. Ann Surg 2011;254:48-54.

McIntosh J, Earnshaw JJ. Antibiotic prophylaxis for the prevention of infection after major limb amputation. Eur J Vasc Endovasc Surg 2009;37:696-703.

Tamma PD, Avdic E, Li DX, Dzintars K, Cosgrove SE. Association of adverse events with antibiotic use in hospitalized patients. JAMA Intern Med 2017;177:1308-15.

Refbacks

  • There are currently no refbacks.